This study investigated the utility of neutrophil biomarkers fecal calprotectin (fCal) and fecal myeloperoxidase (fMPO) in predicting a complicated IBD course.
Many people regularly suffer from heartburn, and look for relief in medications. A recent study checked if mineral water containing bicarbonate can also improve symptoms.
People occasionally treat themselves to a cheat day, a day of indulging in unhealthy food and drink. But even infrequent consumption leaves a mark.
In this cohort study including 177 422 veterans with a diagnosis of dementia, a high Fibrosis-4 score suggestive of advanced liver fibrosis to cirrhosis was observed in 5% to 10% of the patients who previously did not have a diagnosis of cirrhosis. These findings were supported by 2 validation cohorts within the Richmond VA Medical Center.
In this review, we summarize the data behind the relationship of CRC in post-appendectomy patients, discuss the role of the microbiome in relation to appendectomy and CRC pathogenesis, and provide an appraisal of our current understanding of the function of the appendix.
Based on the results, smoking, alcohol, inactivity, high intake of sweets and desserts, low intake of fiber, depression, visceral fat, and obesity are considered as risk factors for GERD. Modifying lifestyle and behavioral habits prevent GERD.
We analyzed 52 biomarkers on 1,710,973 spatially resolved single cells to determine cell types, cell-cell contacts, and cellular neighborhoods. We observed that cellular functional states are associated with cellular neighborhoods.
Using the global burden of disease (GBD) database spanning 1990 to 2019, we evaluated the temporal trends of age-standardized incidence rates (ASIR), age-standardized death rates (ASDR), and age-standardized disability-adjusted life years (AS-DALYs) for GD using estimated annual percentage changes (EAPC).
Of 654 patients, 246 (38%) were readmitted, and 29 (12%) were preventable readmissions. Reviewers agreed on preventability for 70% of readmissions. Twenty-two (including 2 with preventable readmission) died.
New guidelines highlight the reliability of blood and faecal tests to monitor inflammation degrees in CD, thus reducing invasive endoscopy frequencies.
Data demonstrate that the anti-CD40 colitis model shows key features of IBD observed in the human disease, hence making it a suitable model to investigate the pathophysiology of ulcerative colitis (UC).
Who thinks instantly of bowel cancer when abdominal pain or diarrhoea hits? It turns out, these complaints may be key symptoms of early colorectal cancer.
A preclinical study highlights the potential of SIWA318H, an antibody targeting advanced glycation end-products, in the fight against pancreatic cancer.
The acute aspirin challenge significantly increased intestinal permeability similarly in both groups, and prophylactic probiotic consumption was unable to prevent the loss in this particular model.
This review outlines the current management of pancreatic cancer, and the recent advances in its treatment. The review discusses future treatment pathways aimed at integrating novel findings of translational and clinical research.
The burden of perianal disease and perianal surgery rates were high in this cohort. Therapeutic strategy was accelerated in patients with perianal Crohn's over time with higher exposure to immunosuppressives and biologics.
In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension.
Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk.
Is Agent Orange (AO) exposure during the Vietnam War (1966 to 1975) associated with incident hepatocellular carcinoma (HCC)? These findings suggest that AO exposure is not associated with incident HCC.
This systematic review and meta-analysis of inflammatory bowel disease in Oceania found high incidence rates (19.8 [95% confidence interval, 15.8-23.7] per 100 000 person-years) and prevalence rates (303.3 [95% confidence interval, 128.1-478.4] per 100 000 persons).