A 55-year-old woman suffers paraplegia, anemia, and recurrent infections. What is the underlying diagnosis?
Lugol’s chromoendoscopy (LCE)–based detection of esophageal squamous cell neoplasia (ESCN) is limited by low specificity. High-resolution microendoscopy (HRME) was shown to improve specificity and reduce unnecessary biopsies when used by academic endoscopists. In this international randomized controlled trial, we determined the clinical impact, efficiency, and performance of HRME in true global health contexts with a range of providers.
Using a multi-omics approach, this study investigated Clostridioides difficile infection (CDI) as a direct contributor to hepatic dysmetabolism. Fifty-four C57BL/6 mice were divided into Control, Antibiotic control (Abx), and C. difficile-infected (C. diff) groups.
Celiac disease is associated with higher osteoporosis risk. A recent study suggests that muscle mass, BMI and bone health may be linked in those affected.
We conducted a comprehensive literature search in databases from inception to July 2024. Subgroup analyses and meta-regression were performed to determine factors associated with HBsAg seroclearance, including ethnicity, HBV genotype, NA therapy duration, end-of-treatment (EOT) qHBsAg levels, HBeAg status, cirrhosis status, and follow-up duration.
Colonoscopy surveillance for Lynch syndrome is burdensome and postcolonoscopy colorectal cancers (CRCs) still occur. The noninvasive fecal immunochemical test (FIT) might guide optimal colonoscopy intervals.
In this study, we aimed to construct an explainable ML model to calculate the risk of mortality in patients with AP admitted in intensive care unit (ICU) and compared it with existing scoring systems.
This study aimed to describe the epidemiology of end-organ complications from alcohol among AYAs over the past 2 decades in the general population.
Intracellular MTX–polyglutamates (PG1–5), which accumulate over time, have not been assessed in pediatric inflammatory bowel disease (IBD). This study aimed to evaluate erythrocyte MTX-PG as a potential TDM tool in pediatric IBD.
Faced with challenging cases, doctors are increasingly seeking diagnostic advice from large language models (LLMs). This study aims to compare the ability of LLMs and human physicians to diagnose challenging cases. An offline dataset of 67 challenging cases with primary gastrointestinal symptoms was used to solicit possible diagnoses from seven LLMs and 22 gastroenterologists.
The deficiency of the anion transporter PAT1 leads to a disrupted intestinal barrier, microbial dysbiosis and increased susceptibility to intestinal inflammation.
In cases of malignant colonic obstruction (MCO), self-expandable metallic stents (SEMS) are used as a bridge to surgery, offering an alternative to emergency surgery. However, the long-term oncologic outcomes remain debated, particularly in developing countries where the cost of SEMS is a concern.
The purpose of the present study was to establish a prognostic model of CRGs and provide directions for the diagnosis and treatment of GC. Transcriptome and clinical data of patients with GC were collected from The Cancer Genome Atlas and Gene Expression Omnibus datasets.
Selenium deficiency is a common find in inflammatory bowel diseases. Recent studies emphasise that there is a benefit in selenium intake for these patients.
Primary sclerosing cholangitis (PSC) may reoccur following liver transplantation (LT), and the diagnosis established once imaging studies demonstrate the diagnostic cholangiographic appearance. To evaluate whether the development of recurrent PSC (rPSC) is associated with cholestasis soon after LT, we studied whether changes in hepatic biochemistry within the first 12 months were linked with the development of rPSC and graft loss.
Circulating albumin concentrations are frequently measured in clinical practice. This review explores biochemical properties and physiological roles of albumin, its place in nutritional assessment, current understanding of perturbed circulating concentrations, and role in clinical management, with special focus on patients with inflammatory bowel disease (IBD).
Persons with inflammatory bowel disease exhibit a weaker relationship between executive function and functional connectivity of cerebellar regions (VIIa Crus I and VIIa Crus II) to cortical areas involved in visual processing compared to healthy counterparts with comparable performance.
In this randomized clinical trial that included 1254 adults, the AQCS-assisted group achieved a significantly higher adenoma detection rate vs the standard colonoscopy group (32.7% vs 22.6%).
GABD continue to pose a significant global public health challenge, particularly affecting women and the elderly population. Consequently, the implementation of effective interventions to mitigate the GABD burden is of paramount importance.
We analyzed a nationwide sample of United States Medicare beneficiaries hospitalized from 2017-2019 for common gastrointestinal diseases, grouped by Diagnosis Related Groups (DRGs).