Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
Researchers used a new statistical method to identify the genetic basis of the link between red and processed meat intake and colorectal cancer risk.
Do patients with non-erosive gastro-oesophageal reflux need regular follow-up endoscopies to prevent cancer? A long-term cohort study argues against this.
A recent study argues for a treatable cause behind dementia symptoms: hepatic encephalopathy, in the context of unrecognised liver cirrhosis.
We observed that night eating syndrome was very common in esports players and that these individuals were at risk in terms of food addiction. Since esports has a more sedentary structure than traditional sports, we suggest that esports players should be evaluated in terms of their unhealthy eating behaviors and risk of eating disorders.
LP reproducibility is feasible under water-perfused HRM, and comparative studies could bring similarity to dataset expansion. Novel 3D parameters need further studies with healthy and larger data to be validated and for disease comparisons.
The results demonstrate that IMR-CNN exhibits superior accuracy compared to MR-CNN in both EGC detection and lesion segmentation. To enhance the robustness of the findings, a rigorous fivefold cross-validation was performed on a self-built dataset, verifying the reliability of the models.
In this cohort study of 1293 patients, the anti–H pylori treatment group had a significant survival advantage compared with the non–anti–H pylori treatment group in terms of overall survival and disease-free survival. After propensity score matching, the survival advantage for both overall and disease-free survival remained.
This study provides insights into medication patterns in pregnant IBD patients and suggests no increased risk of MCMs associated with first-trimester IBD medication use.
Antibiotic resistance is one of the main factors that determine the efficacy of treatments to eradicate Helicobacter pylori infection. Our aim was to evaluate the effectiveness of first-line and rescue treatments against H. pylori in Europe according to antibiotics resistance.
Over 9,000 heart disease deaths could be avoided by 2041 in England if all gastronomy establishments displayed calorie disclaimers on their menus.
Bowel urgency and bowel urgency-related accidents are accompanied by several bothersome symptoms and considerably impact patients’ quality of life, highlighting the need to develop a patient-reported outcome measure for assessing and addressing bowel urgency in clinical settings.
H. pylori is the most common cause of chronic gastritis. However, the antibiotic resistance of various strains is the main reason for the failure of eradication therapy. This requires pre-therapeutic antibiotic susceptibility testing.
Curing malignant melanoma with a faecal transplant may sound far-fetched, but new study results show the potential of microorganisms.
There is a growing consensus that older people have a greater requirement for protein. With a larger and older population, global needs for protein are set to increase. This paper summarises the conclusions from a Rank Prize funded colloquium evaluating novel strategies to meet this increasing global protein need.
The search identified 45 unique pooled analyses, including 13 dose-response associations and 32 non-dose-response associations (n=9 888 373). Overall, direct associations were found between exposure to ultra-processed foods and 32 (71%) health parameters spanning mortality, cancer, and mental, respiratory, cardiovascular, gastrointestinal, and metabolic health outcomes.
Transgender and gender-diverse (TGD) people are more likely than cisgender people to experience adverse health outcomes and health care discrimination. These disparities remain uninvestigated in gastroenterology (GI) and hepatology. Here, we describe what is known about digestive clinical care in TGD people. Practical considerations are offered to assist in the provision of culturally humble care to TGD people.
Here, we developed an ingestible self-propelling device for intestinal reanimation (INSPIRE) capable of restoring peristalsis through luminal electrical stimulation. Optimizing mechanical, material, and electrical design parameters, we validated optimal deployment, intestinal electrical luminal contact, self-propelling capability, safety, and degradation of the device in ex vivo and in vivo swine models.
The study aimed to identify prognostic factors for patients with acute lower gastrointestinal bleeding and to develop a high-accuracy prediction tool. The analysis included 8254 cases of acute hematochezia patients who were admitted urgently based on the judgment of emergency physicians or gastroenterology consultants (from the CODE BLUE J-study).
The aim is to evaluate the relationship between RH (measured by the RBB) and FDD (defined as any minor disorder of rectoanal coordination by the London classification) in constipated patients.