Liver cirrhosis is a complex and progressive condition resulting from sustained liver injury and chronic inflammation. Characterized by extensive fibrosis, disrupted liver architecture, and impaired function, cirrhosis represents the end stage of many chronic liver diseases.
In this multicenter case-control study of 809 specimens from 480 patients in the training and validation cohorts, the 10-microRNA signature Destinex assay demonstrated robust performance for early detection of gastric cancer, achieving high area under the curve values in both the training and validation cohorts.
An international group of experts has spoken out against the routine use of AI-based detection systems in colonoscopies – but why?
Inflammatory bowel disease (IBD) is associated with various extra-intestinal manifestations. We aim to identify comorbidities in IBD and the timing of their development to provide potentially useful insight into the associations with IBD.
Medically refractory ulcerative colitis may require colectomy with ileal pouch-anal anastomosis. Complications of the J-pouch include pouchitis, occurring in 50%-80% of patients, and Crohn’s disease (CD) of the pouch, occurring in 3%-17%. Our aim was to evaluate the efficacy and safety of ustekinumab (UST) and vedolizumab (VDZ) in patients with CD of the pouch.
In the Cystic Fibrosis (CF) modulator era, focus for many has shifted from growth and survival to prevention of diet-related chronic diseases. In doing so, diet quality should be prioritised. However, factors influencing diet quality in CF have yet to be examined. This study aims to explore relationships between health-related quality of life (HRQoL), demographic and clinical characteristics, and diet quality in adults living with CF.
The prognosis of biliary tract cancer (BTC) is poor, and recurrence rates remain high even after curative resection. This study aimed to compare the efficacy and safety of capecitabine and 5-fluorouracil/leucovorin (FL) as adjuvant treatments following curative resection in patients with BTC.
While effective in ascites control, sodium restriction may compromise nutritional status, heighten sarcopenia risk, and increase mortality, highlighting the need for a more individualized dietary approach.
A simple saliva test outperforms the standard questionnaire for reflux cough with 83.6% accuracy. The pepsin test demonstrates its superiority particularly in cases of non-acid reflux.
Here, we develop a reinforcement learning-based AI Clinician system to personalise treatment selection and evaluate its ability to improve eradication success compared to clinician-prescribed therapies.
Small bowel capsule endoscopy is a valuable modality for evaluating small intestinal lesions in children with inflammatory bowel disease. However, its application for very early-onset inflammatory bowel disease remains insufficiently documented.
The evidence suggests that adherence to the Mediterranean diet (MD) may be beneficial in preventing cognitive decline. We aimed to explore this association in a Central European population.
Patients with inflammatory bowel disease (IBD) often consider their gastroenterologist to be the primary provider of care. To improve the care delivered to patients with IBD, health maintenance issues need to be addressed by the gastroenterology team.
In this randomized clinical trial of 81 participants who had completed treatment for a CDI and were taking systemic antibiotics for a non-CDI indication, recurrent CDI occurred in 43.6% of participants in the oral vancomycin group vs 57.1% in the placebo group at 8 weeks. However, the study was underpowered and this difference did not reach statistical significance.
A group of experts from ESMO GI 2025 highlight critical trends and new therapeutic strategies to address the global increase in gastrointestinal cancers.
Although research has established that stress and shift work are independent risk factors for gastrointestinal discomfort and insomnia, the direct link between these two conditions in healthcare workers remains insufficiently explored.
Coins are the most commonly ingested foreign bodies. When they get stuck in the distal esophagus, there is no general agreement about the timing of their removal because some of them may spontaneously migrate into the stomach, no longer requiring removal. We aimed at evaluating the gastric spontaneous passage of esophageal-retained coins, as well as complications.
The association between inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE) remains unclear. We aimed to perform a systematic review and meta-analysis on the association between EoE, IBD, and other immune-mediated inflammatory diseases.
In this diagnostic study of an AI model for gatekeeping that was developed, tested, and validated sequentially, the model differentiated between referrals that warranted immediate authorization and additional information with moderate accuracy and outperformed human gatekeepers by nearly 20%, primarily due to increased specificity.
Early-Onset Gastrointestinal Cancers concerns tumors in people under 50. Accumulating evidence suggests a significant increase in the burden of colorectal cancer in young adults. We investigated the global burden and spatiotemporal trends of the 6 major gastrointestinal (GI) cancers.