After initial results over 5 years ago, long-term follow-up data from 3 clinical trials – CheckMate 067, COLUMBUS, and ABC – show a durable and sustained clinical benefit for patients with melanoma.
First-line treatment of patients with MSI-H/dMMR metastatic colorectal cancer (mCRC) with pembrolizumab improves overall survival, but the prespecified threshold for significance was not reached.
The method is called "Augmented Psychotherapy" and shows how depression can be treated when psychotherapy and psychopharmacology are combined.
The UK notified the WHO of a PCR-confirmed monkeypox case on a patient that lived and worked in Delta State, Nigeria. A second case was confirmed on 31 May 2021.
Polypharmacy in RA is associated with increased disease activity, an increased risk of serious adverse events (AEs), and a decreased treatment response.
The phase 3 OUTBACK trial results do not support the use of adjuvant chemotherapy after chemoradiation in women with locally advanced cervical cancer.
Patients with SLE have an increased risk of developing severe infections compared with non-SLE cases. Moreover, 21% of the mortality in SLE is related to these infections.
A significantly improved invasive disease-free survival in patients with high risk, HER2-negative, germline BRCA1/2-mutated primary breast cancer is found after 1 year of adjuvant treatment with olaparib.
Adhering to the healthy Dietary Approaches to Stop Hypertension (DASH) diet decreased the risk of gout in women. This effect was more pronounced in genetically predisposed individuals.
Adding the BCL2 inhibitor venetoclax to endocrine therapy does not improve clinical benefit for ER-positive, HER2-negative, locally advanced/metastatic breast cancer patients.
Risankizumab treatment leads to better-than-placebo signs and symptoms in active PsA patients with inadequate response or intolerance to 1 or 2 biologic therapies or at least one DMARD therapy.
First phase-3 CheckMate 648 study results demonstrate higher first-line treatment OS with nivolumab + ipilimumab, or nivolumab + chemotherapy, versus chemotherapy only.
esanum provides an overview of how you as a medical professional can help and proactively support humanitarian and medical aid projects.
A study investigated the safety profiles of COVID-19 vaccines in patients with rheumatic and musculoskeletal diseases (RMD) finding that these vaccines are safe and well tolerated in these patients.
A CheckMate 9LA trial update shows sustained benefit of first-line treatment with nivolumab plus ipilimumab plus 2 cycles of chemotherapy versus chemotherapy alone in patients with advanced NSCLC.
On 31 May 2021 China's National Health Commission notified WHO of one confirmed case in Zhenjiang City, Jiangsu Province. The patient is in a stable condition.
Addition of 177Lu-PSMA-617 therapy to standard of care for mCRPC patients significantly improves survival, according to the phase-3 VISION trial results.
RBN-2397 is a potent, selective inhibitor of PARP7 that could potentially release the brake on the antitumour immunity, is well tolerated, and demonstrated proof of mechanism in a first-in-human trial.
Severe COVID-19 outcomes risk in RA patients is 4 times higher for rituximab, and 2 times higher for JAK inhibitor users compared to TNF inhibitor users. This was not found for abatacept or IL-6-inhibiting DMARDs.
Secukinumab significantly increased the time leading to, and reduced the number of flares in children with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) when compared with placebo.