• Could poor air quality in aeroplanes pose health risks?

    The air you breathe in aircrafts is routinely contaminated by small amounts of engine oils and hydraulic fluids. Could these pollutants be harmful?

  • Gynaecological oncology: present and future

    During the ESMO Congress on Gynaecological Cancers, Prof. Scambia analysed developments in the field, and what's next in the coming decade.

  • Colon carcinoma: current biomarker tools and new developments

    Precision medicine is revolutionising treatments for colon cancer and other gastrointestinal malignancies by identifying biomarkers for personalised therapies.

  • New targets in immunotherapy

    New immunotherapies go beyond CTLA-4 and PD(L)1 and show promising results for treating various types of cancer, including colorectal cancer.

  • The Margarita Burn: A summer holiday phytophotodermatitis

    Summer season is coming, and with it, time by the pool; but also possibly some more cases of “Margarita burn” or phytophotodermatitis.

  • Survival benefits: haemodiafiltration outperforms haemodialysis

    In a first, haemodiafiltration was shown to have a lower risk of death than haemodialysis. Results could change current dialysis practice.

  • First results for zanubrutinib plus venetoclax in del(17p)/TP53-mutated CLL/SLL

    The combination was associated with deep and durable responses in previously untreated high-risk CLL, SLL, and del(17p) and/or TP53 mutations.

  • Clinically meaningful outcomes for mosunetuzumab across FL subgroups

    High-risk participants with heavily pre-treated relapsed or refractory follicular lymphoma benefitted in clinical remission and survival outcomes.

  • AUGMENT-101: revumenib trial in KMT2Ar leukaemia stopped early for efficacy

    In a heavily pretreated population of participants with KMT2A rearranged acute leukaemia, revumenib displayed encouraging anti-tumour activity.

  • Traffic noise could contribute to cardiovascular diseases

    Harmful environmental influences, such as air and noise pollution or light pollution at night, can also contribute to susceptibility to disease.

  • ESLIM-01: Sovleplenib delivers durable responses and QoL improvements in primary ITP

    Sovleplenib was associated with early and durable platelet responses in participants with primary immune thrombocytopenia.

  • RUBY: Promising data for first AsCas12a gene-editing therapy in sickle cell disease

    Renizgamglogene autogedtemcel (reni-cel) established a swift and durable normalisation in haemoglobin and improvements in haemolysis markers.

  • Excellent phase 3 results for asciminib in CML

    Asciminib was superior to all other tested first-line tyrosine kinase inhibitors (TKIs) in participants with chronic myeloid leukaemia (CML).

  • EPCORE CLL-1: promising data for epcoritamab in high-risk Richter’s transformation

    Epcoritamab delivered encouraging efficacy data and a favourable safety profile in participants with high-risk Richter’s transformation (RT).

  • ENERGIZE: mitapivat meets primary efficacy endpoint in thalassaemia

    Mitapivat improved Hb levels and fatigue in participants with non-transfusion-dependent alpha or beta thalassaemia (NTDT) in a phase 3 study.

  • Is pelabresib plus ruxolitinib the paradigm-shifting combo therapy for MF?

    Treatment with pelabresib plus ruxolitinib was associated with improvements in all 4 hallmarks of myelofibrosis, the phase 3 MANIFEST-2 trial showed.

  • Navitoclax plus ruxolitinib leads to spleen volume reductions in MF in TRANSFORM-1 trial

    JAK inhibitor-naïve participants with myelofibrosis benefitted from a regimen of navitoclax plus ruxolitinib compared with ruxolitinib and a placebo.

  • Beans: powerful supporters in colorectal cancer aftercare

    The intestinal microbiome is essential in many body processes. Could prebiotic food intake benefit intestinal flora in intestinal polyps or colorectal carcinoma?

  • Promising results for novel CAR T-cell therapy in MM in phase 1 trial

    Anitocabtagene autoleucel (anito-cel) yielded excellent efficacy results in heavily pre-treated participants with relapsed or refractory multiple myeloma.

  • Isa-VRd proves its value in newly diagnosed MM in the IMROZ trial

    Isatuximab with bortezomib, lenalidomide + dexamethasone yielded better outcomes than VRd alone for first-line treatment of transplant-ineligible cases.

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