Myelofibrosis

Myelofibrosis is a rare myeloproliferative disorder, in which a defect in the stem cells leads to an increased formation of new bone marrow and blood cells.

This results in increased fibrosis of the bone marrow which attenuates hematopoiesis. Finally, the blood formation in other organs, such as spleen and liver, must be relocated. The disease is not inheritable according to current scientific proof. It is thought that the disorder is based on a change in stem cells in the bone marrow. However, there may be a familial accumulation of JAK2 mutations throughout life.

Symptoms of this disease include fatigue, decreased performance, weight loss, night sweats, hepato- and splenomegaly, anemia, itching and bone pain.