Mal de Meleda

Mal de Meleda is an autosomal recessive inherited skin disease, and is caused by a mutation in the SLURP1 gene. Meleda disease is a special form of erythrocyte adenoma.

Those affected suffer from palmoplantar keratoses, which occur symmetrically on the backs of the hands, knuckles, forearms, back of the feet, lower legs and neck. The hyperkeratoses are discolored yellow-brown. Hyperhidrosis occurs in its center and its margin is erythematous. The hyperkeratoses form rhagades.

The first symptoms occur between the third and tenth month after birth or until the third year of life.