CDAGS Syndrome

Craniosynostosis-anal anomalies-porokeratosis syndrome or CDAGS syndrome is characterized by craniosynostosis and clavicle hypoplasia (C), late fontanel closure (D), anal malformations (A), genitourinary tract abnormalities (G), and rash (S).

The disease is inherited as an autosomal recessive trait. The reason is a mutation on chromosome 22 at the locus 22q12-q13. The genetic disposition is still part of the research, one factor is the toxin exposure during pregnancy.