Carney complex

The Carney complex describes the combination of multiple myxomas, increased pigmentation and hormonal regulatory disorders.

The cause of the disease is usually a result of a gene mutation on the PRKAR1A gene whose gene product acts as a tumor suppressor among other things. The trait is inherited autosomal dominant. The carriers of the mutation fall ill neonatally or in the early infancy. 

Symptoms include lentigines and blue nevi, acromegaly, thyroid tumors and fibroids, especially in the heart. If the adrenal gland is affected, the development of Cushing's syndrome is possible. 

The prognosis is dependant of the the severity of the symptoms. A regular medical check-up is necessary.