Amyloidoses

Amyloidoses cause deposits of fibrillar protein in the intercellular space of various organs. This results in impaired functional ability or even loss of function of the affected organs.

Amyloidoses can be classified according to the proteins involved (AA, AL, AE, AP amyloidoses) and causes.

Primary amyloidoses is associated with plasma cell stasis. Altered antibodies can not be completely degraded.

Secondary amyloidosis develops as a result of chronic infectious diseases.
In familial amyloidosis, there is a hereditary synthesis disorder in the liver.
Depending on which organ is affected, other symptoms arise. If the kidneys are affected, it can lead to kidney failure.

When the heart is affected, cardiomyopathy or cardiac arrhythmia can occur. Deposits in the gastrointestinal tract lead to diarrhea. Visual disturbances can occur in deposits in the eye.