Acrogeria

Acrogeria is a congenital disorder characterized by a dermal predominant condition characterized by atrophy of the skin and loss of subcutaneous adipose tissue.

Symptoms mainly occur in the face and the acres, as hyperpigmentation, dryness, and wrinkles and associated prematurely aged appearance. The disease begins in infancy or early childhood.

It is believed that the inheritance is autosomal recessive, with the female sex significantly more affected.

The cause may be a mutation in the COL3A1 gene at the gene site 2q32.2, which interferes with the biosynthesis of type III collagen. However, this could only be confirmed in some cases.