Adrenocortical carcinoma

Adrenocortical carcinoma is a rare malignant tumor located in the outermost layer of the adrenal glands. It can be either endocrine active or inactive. The cause of adrenocortical carcinoma is still unclear. However, adrenogenital syndrome is seen as a risk factor.

Affected above all are children and adults around the age of 50 years. 

The tumor is often detected either by its increasing size and the symptoms it triggers (e.g. vomiting, abdominal pain) or by its hormone production, which in turn produces symptoms (Cushing's syndrome, acne, lower voice etc). 

Unfortunately, the prognosis of those affected is poor. The 5-year survival rate is only 5%.