AA amyloidosis

AA amyloidosis can occur in any chronic inflammatory disease (e.g. chronic osteomyelitis, tuberculosis). Rheumatic diseases, chronically infected wounds and chronic inflammatory bowel and liver diseases are often the cause of the disease, which usually occurs in the gastrointestinal tract, kidneys and the adrenal glands, as well as in the spleen.

Persistent or periodically increased signs of an inflammation increase the risk of AA amyloidosis independent of the symptoms of the triggering disease.

Increased levels of the acute phase proteins CRP and SAA, which are synthesized in the liver under the influence of IL-6, are shown. TNF alpha also plays an important role in inflammatory rheumatic diseases.