Rosai-Dorfman disease

The Rosai-Dorfman disease belongs to the group of histiocytoses and is characterized by a proliferation of histiocytes, which accumulate in the lymph nodes. Because of the enlargement of the sine of the lymph nodes caused by emperipolesis, a bilateral widening of the lymph nodes comes to show.

At the same time an increase of plasma cells, lymphocytes and neutrophilic granulocytes takes place in the sinuses.

Mainly people with dark skin color are affected, but there are also a few cases in Europe, especially in adolescents aged 15-20 years. The cause is a mutation of the SLC29A33 gene, which is encoded for a nucleoside transporter.

As the cause of the disease, a virus infection is suspected.