Lambert-Eaton myasthenic syndrome

Lambert-Eaton myasthenic syndrome is an autoimmune disease of the peripheral nervous system. This paraneoplastic neuromuscular disorder inhibits the release of neurotransmitters.

Namely, the body forms autoantibodies against presynaptic, voltage-dependent calcium channels, resulting in a reduced amount of acetylcholine. Affected are the signal transmission to the motor end plate and muscarinic synapses of the autonomic nervous system.

This leads to muscle weakness and stiffness of the proximal leg muscles and pelvic muscles. The walking distance of the patient is reduced and there are difficulties in climbing stairs. The shoulder and respiratory muscles can also be affected. In affected eye muscles, this leads to ptosis and to double vision and accommodation disorders.

Autonomic disorders include hypohidrosis, dry mouth, constipation, bladder discomfort, and erectile dysfunction.