Catel-Manzke syndrome

Catel-Manzke syndrome is a bone disorder with bilateral hyperphalangia and clinodactyly of the index finger. Typically it is associated with the symptoms of the Pierre-Robert sequence, including microgia, cleft palate, and glossoptosis. The syndrome is sex-linked.

Mutations in the TGDS gene at the locus 13q32.1 could be identified. In some cases autosomal recessive inheritance could be confirmed.